Splicing variant of <i>WDFY4</i> augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis.

Author
:
Y Kochi
Y Kamatani
Y Kondo
A Suzuki
E Kawakami
R Hiwa
Y Momozawa
M Fujimoto
M Jinnin
Y Tanaka
T Kanda
RG Cooper
H Chinoy
S Rothwell
JA Lamb
J Vencovský
H Mann
K Ohmura
K Myouzen
K Ishigaki
R Nakashima
Y Hosono
H Tsuboi
H Kawasumi
Y Iwasaki
H Kajiyama
T Horita
M Ogawa-Momohara
A Takamura
S Tsunoda
J Shimizu
K Fujio
H Amano
A Mimori
A Kawakami
H Umehara
T Takeuchi
H Sano
Y Muro
T Atsumi
T Mimura
Y Kawaguchi
T Mimori
A Takahashi
M Kubo
H Kohsaka
T Sumida
K Yamamoto
Abstract
:

Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases in which both genetic and environmental factors play important roles. To identify genetic factors of IIM including polymyositis, dermatomyositis (DM) and clinically amyopathic DM (CADM), we performed the first genome-wide association study for IIM in an Asian population.
Year of Publication
:
2018
Journal
:
Annals of the rheumatic diseases
Date Published
:
2018
ISSN Number
:
0003-4967
URL
:
http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=29331962
DOI
:
10.1136/annrheumdis-2017-212149
Short Title
:
Ann Rheum Dis
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