Environmental enrichment produces a behavioral phenotype mediated by low cyclic adenosine monophosphate response element binding (CREB) activity in the nucleus accumbens.
| Author | |
| Abstract |
:
Previous research has shown that rats reared in an enriched condition (EC) are more sensitive to the acute effects of amphetamine than rats reared in an isolated condition (IC); yet, EC rats self-administer less amphetamine than IC rats. The present study used cocaine to further explore this environmental enrichment behavioral phenotype, as well as the underlying molecular mechanisms involved. |
| Year of Publication |
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2010
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| Journal |
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Biological psychiatry
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| Volume |
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67
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| Issue |
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1
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| Number of Pages |
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28-35
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| Date Published |
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2010
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| ISSN Number |
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0006-3223
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| URL |
:
https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(09)00830-0
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| DOI |
:
10.1016/j.biopsych.2009.06.022
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| Short Title |
:
Biol Psychiatry
|
| Download citation |
