Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice.
| Author | |
|---|---|
| Abstract |
:
Sleep disruption is a characteristic of Alzheimer's disease (AD) that may exacerbate disease progression. This study tested whether a dual orexin receptor antagonist (DORA) would enhance sleep and attenuate neuropathology, neuroinflammation, and cognitive deficits in an AD-relevant mouse model, 5XFAD. |
| Year of Publication |
:
0
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| Journal |
:
Alzheimer's & dementia (New York, N. Y.)
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| Volume |
:
5
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| Number of Pages |
:
70-80
|
| Date Published |
:
2019
|
| DOI |
:
10.1016/j.trci.2019.01.003
|
| Short Title |
:
Alzheimers Dement (N Y)
|
| Download citation |
